Pure Methyltetrahydrofolate Calcium（5MTHF-Ca)

The difference between the fourth generation of folic acid (5-MTHF) and traditional folic acid lies in their chemical structure and bioavailability in the body.

Chemical structure:  Traditional folic acid is a synthetic form of folate that needs to undergo multiple conversion steps in the body before it can be utilized. On the other hand, Fourth-generation folic acid, also known as 5-MTHF or Methyltetrahydrofolate, is the active, bioavailable form of folate that does not require conversion.

Bioavailability:  Traditional folic acid needs to be converted to its active form, 5-MTHF, through enzymatic reactions in the body. This conversion process varies among individuals and can be influenced by genetic variations or other factors. In contrast, 5-MTHF is already in its active form, making it readily available for cellular uptake and utilization.

Absorption and utilization:  Absorption of traditional folic acid occurs in the small intestine, where it needs to undergo conversion to the active form by the enzyme dihydrofolate reductase (DHFR). However, this conversion process is not very efficient for some individuals, leading to lower bioavailability. 5-MTHF, being the active form, is readily absorbed and utilized by the body, bypassing the conversion process. This makes it a preferred form for individuals with genetic variations or conditions that affect folate metabolism.

Fitness for certain individuals:  Due to the differences in absorption and utilization, 5-MTHF is considered more suitable for individuals with certain genetic variations, such as MTHFR gene mutations, which can impair the conversion of folic acid to its active form. For these individuals, using 5-MTHF directly can ensure proper folate levels in the body and support various biological functions.

Supplementation:  Traditional folic acid is commonly found in supplements, fortified foods, and processed foods, as it is more stable and less expensive to produce. However, there is growing availability of 5-MTHF supplements that provide the active form directly, which can be beneficial for individuals who have difficulty converting folic acid.

The side effects of Fourth-generation folic acid (5-MTHF) are generally rare and mild, but it's important to be aware of potential reactions:

Allergic reactions:  Like any supplement or medication, allergic reactions are possible. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing. If you experience any of these symptoms, seek immediate medical attention.

Digestive issues:  Some individuals may experience gastrointestinal discomforts, such as nausea, bloating, gas, or diarrhea. These symptoms are usually temporary and subside as the body adjusts to the supplement.

Interactions with medications: 5-MTHF may interact with certain medications, including medications used for cancer treatment, anticonvulsants, methotrexate, and certain antibiotics. It's important to talk to your healthcare provider if you are taking any medications to ensure there are no potential interactions.

Overdose or excess folate levels:  While rare, excessive intake of folate (including 5-MTHF) can lead to high blood levels of folate. This may mask the symptoms of vitamin B12 deficiency and affect the diagnosis and treatment of certain conditions. It's important to follow the recommended dosage and consult a healthcare professional for guidance.

Other considerations:  Pregnant women or those planning to become pregnant should talk to their healthcare provider before taking higher doses of 5-MTHF, as excessive folate intake can mask symptoms of vitamin B12 deficiency, which is important for neural tube development in the fetus.

As with any dietary supplement or medication, it's necessary to discuss the use of Fourth-generation folic acid (5-MTHF) with a healthcare provider, especially if you have any underlying health conditions or are taking other medications. They can provide individualized advice based on your specific needs and help monitor for any potential side effects.

Fourth-generation folic acid, also known as 5-methyltetrahydrofolate (5-MTHF), is a biologically active form of folate that is more readily absorbed and utilized by the body compared to traditional folic acid supplementation. Here are some scientific studies that support its effectiveness:

Increased bioavailability:  5-MTHF has been shown to have greater bioavailability than folic acid. A study published in the American Journal of Clinical Nutrition compared the bioavailability of folic acid and 5-MTHF in healthy women. It found that 5-MTHF was more rapidly absorbed and led to higher folate levels in red blood cells.

Improved folate status:  Several studies have demonstrated that supplementation with 5-MTHF can effectively increase blood folate levels. In a randomized controlled trial published in the Journal of Nutrition, researchers compared the effects of 5-MTHF and folic acid supplementation on folate status in healthy women. They found that 5-MTHF was more effective in increasing red blood cell folate levels than folic acid.

Enhanced folic acid metabolism:  5-MTHF has been shown to bypass the enzymatic steps required for folic acid activation and directly participate in cellular folic acid metabolism. A study published in the Journal of Nutrition and Metabolism demonstrated that 5-MTHF supplementation improved intracellular folate metabolism in individuals with genetic variations in the enzymes involved in folic acid activation.

Reduced homocysteine levels:  Elevated levels of homocysteine, an amino acid in the blood, are associated with increased risk of cardiovascular diseases. Studies have shown that 5-MTHF supplementation can effectively reduce homocysteine levels. A meta-analysis published in the Journal of the American College of Nutrition analyzed 29 randomized controlled trials and concluded that 5-MTHF supplementation was more effective than folic acid in reducing homocysteine levels.

It is important to note that individual responses to supplementation may vary, and the effectiveness of 5-MTHF may depend on factors such as genetic variations in folate metabolism enzymes and overall dietary intake. It's always recommended to consult with a healthcare provider for personalized advice regarding supplementation and to discuss any specific health concerns or conditions.