Pure Rotundine Powder(l-tetrahydropalmatine，l-THP)
Rotundine, also known as l-tetrahydropalmatine (l-THP), is a compound with pharmacological properties that affect the central nervous system and cardiovascular system. It has been reported to have analgesic, sedative, hypnotic, and anxiolytic effects. Additionally, it has been shown to have protective effects on cerebral and myocardial ischemia-reperfusion injury. Rotundine is also known for its potential to reverse multidrug resistance in cancer cells and its calcium channel-blocking properties.
It can be gained from the tubers of Stephania tetrandra and Corydalis yanhusuo, or by chemical synthesis methods. Synthesized from tetrahydropalmatine through reduction, cleavage, and alkalization reactions. Iodinated tetrahydropalmatine can be produced from tetrahydropalmatine through alkalization and oxidation for repeatable synthesis.
For pharmacokinetics, Rotundine is well absorbed after oral administration and is primarily distributed in adipose tissue, followed by the lungs, liver, and kidneys. It is mainly excreted through the kidneys. Studies in rodents and rabbits have indicated that Rotundine can penetrate the blood-brain barrier and enter brain tissue, with brain concentrations lower than blood concentrations after 2 hours.
For adverse effects, Rotundine may cause drowsiness, dizziness, fatigue, nausea, and occasionally allergic shock. Precautions include avoiding use in pregnant and lactating women, being aware of the potential for tolerance with long-term use, and using caution when co-administering with central nervous system depressants, with appropriate dosage adjustments if necessary.
In summary, Rotundine is a compound with diverse pharmacological effects, and its properties make it a subject of interest in various research, including pain management, cardiovascular health, and cancer treatment. For more information contact grace@biowaycn.com.
Pain relief: Rotundine has been shown to have analgesic properties, making it effective in reducing pain and discomfort.
Anti-inflammatory effects: Rotundine has demonstrated anti-inflammatory properties, which can help reduce inflammation and associated symptoms.
Relaxation and sedation: Rotundine has been used to promote relaxation and sedation, making it potentially beneficial for managing stress and anxiety.
Antioxidant activity: Rotundine has been found to exhibit antioxidant effects, which can help protect cells from damage caused by free radicals.
Potential for addiction treatment: Some research suggests that Rotundine may have the potential to manage addiction and withdrawal symptoms, particularly for opioid dependence.
Gastrointestinal benefits: Rotundine has been studied for its potential to alleviate gastrointestinal issues, such as spasms and discomfort.
| Analysis | Specification |
| Assay | Tetrahydropalmatine ≥98% |
| Appearance | Light yellow powder to white Powder |
| Ash | ≤0.5% |
| Moisture | ≤5.0% |
| Pesticides | Negative |
| Heavy metals | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Odor | Characteristic |
| Particle size | 100%through 80 mesh |
| Microbiological : | |
| Total of bacteria | ≤1000cfu/g |
| Fungi | ≤100cfu/g |
| Salmgosella | Negative |
| Coli | Negative |
Rotundine has applications in several industries, including:
Pharmaceutical Industry: Rotundine is used in the pharmaceutical industry for its potential analgesic, sedative, and anxiolytic properties. It may be incorporated into medications for pain management and anxiety relief.
Healthcare and Wellness: Due to its reported health benefits, Rotundine may be utilized in healthcare and wellness products aimed at promoting relaxation and managing pain.
Research and Development: Rotundine is of interest in research and development efforts focused on cardiovascular health, cancer treatment, and neurological conditions due to its reported effects on these systems.
Nutraceuticals: There is potential for the inclusion of Rotundine in nutraceutical products designed to support overall health and well-being.
It’s important to note that the specific applications of Rotundine may vary based on regulatory approvals and ongoing research in each industry.
Our Products are manufactured using stringent quality control measures and adhere to high standards of production processes. We prioritize the safety and quality of our product, ensuring that it meets regulatory requirements and industry certifications. This commitment to quality aims to establish trust and confidence in the reliability of our product. The general production process is as follows:
Storage: Keep in a cool, dry, and clean place, Protect from moisture and direct light.
Bulk Package: 20~25kg/drum.
Lead Time: 7 days after your order.
Shelf Life: 2 years.
Remark: Customized specifications can be achieved.
Express
Under 100kg, 3-5Days
Door to door service easy to pick up the goods
By Sea
Over300kg, Around 30 Days
Port to port service professional clearance broker needed
By Air
100kg-1000kg, 5-7Days
Airport to airport service professional clearance broker needed
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