Sinomenine Hydrochloride Powder
Sinomenine Hydrochloride is a chemical compound derived from the plant Sinomenium acutum, which is commonly found in East Asia. It is an alkaloid that has been traditionally used in Chinese medicine for its anti-inflammatory and analgesic properties. The hydrochloride form is a salt that enhances the compound’s solubility and stability, making it more suitable for pharmaceutical use.
Sinomenine Hydrochloride has been studied for its potential therapeutic effects in treating conditions such as rheumatoid arthritis, due to its ability to modulate the immune system and reduce inflammation. It works by inhibiting the production of pro-inflammatory cytokines and other mediators involved in the inflammatory response.
In addition to its anti-inflammatory and analgesic effects, Sinomenine Hydrochloride has also shown potential in neuroprotection, anti-fibrosis, and anti-tumor activities in various preclinical studies.
Formal Name：(9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride
CAS Number：6080-33-7
Synonyms：Cucoline NSC 76021
Molecular Formula： C19H23NO4 • HCl
Formula Weight：365.9
Purity：≥98% A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 5 mg/ml
PBS (pH 7.2): 5 mg/ml
Origin：Plant/Sinomenium acutum
Shipping & Storage Information：
Storage -20°C
Shipping： Room Temperature
Stability：≥ 4 years
| Item | Specification | Result |
| Assay(HPLC) | 98.0% | 98.12% |
| Appearance | white Powder | Complies |
| Particle Size | 98%through 80mesh | Complies |
| Odor | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Physical Characteristics | ||
| Loss on Drying | ≤0.5% | 0.38% |
| Ash | ≤0.5% | 0.46% |
| Heavy metals | ||
| Heavy metals(as Pb) | USP standards(<10ppm) | <10ppm |
| Arsenic(As) | ≤2ppm | 0.78ppm |
| Lead (Pb) | ≤2ppm | 1.13ppm |
| Cadmium(Cd) | ≤lppm | 0.36ppm |
| Mercary(Hg) | ≤0.1ppm | 0.01ppm |
| Pesticide Residue | Non-detected | Non-detected |
| Total PlateCount | NMT 10000cfu/g | 680 cfu/g |
| Total Yeast &Mold | NMT 100cfu/g | 87 cfu/g |
| E.Coli | NMT 30cfu/g | 10 cfu/g |
| Salmonella | Negative | Negative |
| Conclusion | Conforms to Enterprise Standard | |
The main effects of Sinomenine Hydrochloride include:
(1) Anti-inflammatory: Reduces inflammation.
(2) Analgesic: Provides pain relief.
(3) Immunosuppressive: Suppresses immune system activity.
(4) Anti-rheumatic: Treats rheumatoid arthritis.
(5) Neuroprotective: Protects nerve cells from damage.
(6) Anti-fibrotic: Prevents or reduces tissue fibrosis.
Sinomenine Hydrochloride is primarily used in the following areas:
(1) Rheumatology: Treatment of rheumatoid arthritis.
(2) Pain Management: Alleviation of chronic pain.
(3) Anti-inflammatory: Reduction of inflammation.
(4) Immunomodulation: Modulation of the immune system.
(5) Neuroprotection: Potential use in neuroprotective therapies.
The production process of Sinomenine Hydrochloride Powder can be summarized as follows:
Herb Preparation: Cleaning and drying the raw plant material.
Extraction: Using solvents like ethanol to extract sinomenine from the plant material.
Concentration: Evaporating the solvent to concentrate the sinomenine content.
Alkalization: Adjusting the pH to convert sinomenine to its salt form.
Liquid-Liquid Extraction: Purifying with organic solvents like anisole or 1-heptanol.
Washing: Aqueous washing to remove impurities and solvent traces.
Acidification: Reducing the pH to precipitate sinomenine hydrochloride.
Crystallization: Forming crystals of sinomenine hydrochloride.
Separation: Centrifuging or filtering to separate the crystals from the solution.
Drying: Removing residual moisture from the crystals.
Milling: Grinding the dried crystals into a fine powder.
Sieving: Ensuring uniform particle size distribution.
Quality Control: Testing for purity, concentration, and microbiological standards.
Packaging: Sterile and secure packaging for distribution.
Storage: Keep in a cool, dry, and clean place, Protect from moisture and direct light.
Bulk Package: 25kg/drum.
Lead Time: 7 days after your order.
Shelf Life: 2 years.
Remark: Customized specifications also can be achieved.
Express
Under 100kg, 3-5Days
Door to door service easy to pick up the goods
By Sea
Over300kg, Around 30 Days
Port to port service professional clearance broker needed
By Air
100kg-1000kg, 5-7Days
Airport to airport service professional clearance broker needed
Bioway Organic has gotten USDA and EU organic, BRC, ISO, HALAL, KOSHER, and HACCP certificates.
