Stephania Extract Cepharanthine Powder
Stephania Extract Cepharanthine Powder is a substance derived from the tubers of the plant Stephania cephalantha Hayata(Stephania japonica （Thunb.） Miers) or Stephania epigaea Lo/ Stephania yunnanensis H.S.Lo. Cepharanthine is a natural product isolated from this plant and has been the subject of various studies due to its potential pharmacological properties. It has been found to exhibit anti-SARS-CoV-2 activities, showing effectiveness in suppressing viral proliferation. Additionally, Cepharanthine has demonstrated the ability to reverse P-glycoprotein (P-gp)-mediated multidrug resistance in certain cells and enhance the sensitivity of anticancer agents in experimental models. Furthermore, it has been shown to have inhibitory effects on human liver cytochrome P450 enzymes CYP3A4, CYP2E1, and CYP2C9, and it is associated with antitumor, anti-inflammatory, and antinociceptive effects.
In summary, Stephania Extract Cepharanthine Powder is a powdered form of the natural product Cepharanthine derived from the Stephania cephalantha plant, which has shown potential in various pharmacological applications.
| Product | Cepharanthine |
| CAS | 481-49-2 |
| Assay | 80%~99% |
| Appearance | White powder |
| Packing | 1KG/Foil Bag |
| Item | Specification |
| Appearance | gray white powder, neutral odor, highly hygroscopic |
| Identification | TLC: Standard solution and test solution same spot, RF |
| Assay (Dry Basis) | 98.0%--102.0% |
| Specific Optical | -2.4°~ -2.8° |
| PH | 4.5~7.0 |
| Heavy Metals (As Pb) | ≤10ppm |
| As | ≤1ppm |
| Pb | ≤0.5ppm |
| Cd | ≤1ppm |
| Hg | ≤0.1ppm |
| Related substance | Spot not bigger than standard solution spot |
| Residual solvent | <0.5% |
| Water Content | <2% |
Stephania Extract Cepharanthine Powder is a natural product derived from the plant Stephania cephalantha Hayata. It has been found to possess several pharmacological properties, including:
1. Anti-SARS-CoV-2 activities
2. Inhibitory effects on viral proliferation
3. Reversal of P-glycoprotein-mediated multidrug resistance
4. Enhancement of sensitivity to anticancer agents
5. Inhibitory effects on human liver cytochrome P450 enzymes CYP3A4, CYP2E1, and CYP2C9
6. Antitumor, anti-inflammatory, and antinociceptive effects
The biosynthesis of cepharanthine in Stephania begins with the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA, 5) through norcoclaurine synthase (NCS), yielding norcoclaurine.
Cepharanthine is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). The solubility of cepharanthine in these solvents is approximately 2, 5, and 10 mg/ml, respectively. Cepharanthine is sparingly soluble in aqueous buffers.
The application industries for Stephania Extract Cepharanthine Powder include Pharmaceutical, Nutraceutical, Biotechnology, and Herbal Medicine, the main applications are as follows:
Potential use in antiviral therapies
Potential as an adjuvant in cancer treatment
Potential for use in anti-inflammatory treatments
Potential as an analgesic agent
These applications highlight the diverse potential uses of Stephania Extract Cepharanthine Powder in various therapeutic contexts.
Packaging And Service
Packaging
* Delivery Time: Around 3-5 workdays after your payment.
* Package: In fiber drums with two plastic bags inside.
* Net Weight: 25kgs/drum,Gross Weight: 28kgs/Drum
* Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
* Storage: Stored in a dry and cool place, keep away from strong light and heat.
* Shelf Life: Two years when properly stored.
Shipping
* DHL Express, FEDEX, and EMS for quantities less than 50KG, usually called as DDU service.
* Sea shipping for quantities over 500 kg; and air shipping is available for 50 kg above.
* For high-value products, please select air shipping and DHL express for safety.
* Please confirm if you can make the clearance when goods reach your customs before placing an order. For buyers from Mexico, Turkey, Italy, Romania, Russia, and other remote areas.
Payment And Delivery Methods
Express
Under 100kg, 3-5 Days
Door to door service easy to pick up the goods
By Sea
Over300kg, Around 30 Days
Port to port service professional clearance broker needed
By Air
100kg-1000kg, 5-7 Days
Airport to airport service professional clearance broker needed
Production Details (Flow Chart)
1. Sourcing and Harvesting
2. Extraction
3. Concentration and Purification
4. Drying
5. Standardization
6. Quality Control
7. Packaging 8. Distribution
Certification
It is certified by ISO, HALAL, and KOSHER certificates.
